Current treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
نویسنده
چکیده
The author discusses both the standards of care and more controversial areas in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
منابع مشابه
Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives.
The Philadelphia chromosome (Ph) is the most common cytogenetic abnormality associated with adult acute lymphoblastic leukemia (ALL). Before the advent of tyrosine kinase inhibitors (TKIs), Ph-positive ALL carried a dismal prognosis and was characterized by a poor response to most chemotherapy combinations, short remission durations, and poor survival rates. Outcomes for patients with Ph-positi...
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Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has been associated with the worst patient survival rates of the various acute leukemias. Imatinib mesylate is a novel therapeutic agent that targets the BCR-ABL tyrosine kinase, the molecular abnormality associated with Ph+ ALL. The combination of imatinib with chemotherapy has led to improved and durable treatment respo...
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BACKGROUND Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a reasonable treatment option for this group. We sought to determine the outcome ...
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عنوان ژورنال:
- Haematologica
دوره 95 1 شماره
صفحات -
تاریخ انتشار 2010